The YGC's Hiring Brief – Your Gateway to Biotech's Newest Opportunities | September 12, 2025
This isn’t scraped content. Every role here is vetted through YGC’s insider network — these are the opportunities that actually move careers forward.
The job market moves fast. Your career should move faster.
Each week, we curate the hottest roles in rare disease, gene therapy, oncology, and specialty biopharma — not scraped lists, but insider intel vetted through our network. These are the opportunities that matter: high-impact roles at lean, growing companies where disruption creates opportunity.
While others are slowing down, the real moves are happening now — here are the roles worth your attention.
This Week’s Featured Roles
High-Impact Commercial Roles Hiring Right Now in Rare Disease, Gene Therapy, Oncology & Specialty Biopharma
All jobs are active listings at powerful mission-driven teams. Check them out!
Rare Disease
Associate Director, Patient Marketing & Engagement — argenx
Company Momentum: argenx is riding the wave of VYVGART's commercial success, with the first-in-class neonatal Fc receptor blocker approved for generalized myasthenia gravis (gMG) and chronic inflammatory demyelinating polyneuropathy (CIDP)
Market Opportunity: Targeting dozens of severe autoimmune diseases with a revolutionary mechanism of action
Career Growth: Leading HCP strategy for a transformative rare disease therapy in a rapidly expanding company
Head of Market Access & Patient Services — Dyne Therapeutics
Company Intelligence: $3.5B Market Cap with groundbreaking FORCE™ platform technology
FDA Breakthrough Therapy Designation for DYNE-251 in Duchenne muscular dystrophy
Pipeline Catalyst: DYNE-251 showing unprecedented dystrophin expression levels, targeting BLA submission in early 2026
Strategic Timing: Market access leadership during commercial transition phase offers exceptional career leverage
Field Reimbursement Manager, North Central — Alnylam
Market Position: RNAi Leader: Established platform with multiple approved therapies for rare diseases
Reimbursement Expertise: Critical role managing complex payer relationships for high-cost rare disease therapies
Geographic Advantage: South Central territory coverage offers broad market exposure
Rare Disease Account Manager, Birmingham — Calliditas
Niche Positioning: Specialized Focus: Dedicated rare disease commercial strategy for TARPEYO, the first FDA-approved treatment for IgA nephropathy
Regional Leadership: Alabama territory management for emerging rare disease therapies
Growth Market: Expanding rare disease treatment landscape in nephrology
Gene Therapy
Gene Therapy Leadership: This is a chance to launch an industry-defining product in a white space market, shaping a new standard for ultra-rare CNS diseases
Build From Scratch: The SVP will recruit talent, foster culture, and design organizational strategy from launch onward—a rare opportunity to own blueprint-level work
Pivotal Impact: You'll collaborate frequently with C-suite and board, impacting uniQure's organizational trajectory at a transformative time
Compensation and Growth: SVP roles in gene therapy offer competitive packages, equity, and direct visibility to future CEO paths
Vice President, US Marketing — uniQure
Why It's Attractive: Frontline Leadership: Direct access to regional teams at launch, bridging strategy and real-world execution
Rare Disease Commercialization: Uniquely focused on selling specialty therapies to treatment centers—high visibility and impact
Talent Builder: Influence the next generation of sales/account leadership, fostering a culture of excellence and collaboration
Director, New Product Planning — uniQure
Cross-Functional Opportunity: Portfolio Shaper: Directly influences which gene therapy assets move forward, impacting future company growth
Strategic Exposure: Collaborates deeply with R&D, clinical, regulatory, commercial, and BD—all the decision-makers in biotech product development
Innovation Environment: Ideal for commercial leaders who thrive in high-growth, science-driven settings where new launches are routine
Care Coordinator, Patient Care Navigation — Krystal Biotech
Mission-Driven: Direct patient impact for ultra-rare, previously untreatable conditions with VYJUVEK®, the first redosable gene therapy
Biotech Growth: Become part of a company pioneering redosable gene therapy for dystrophic epidermolysis bullosa
Patient-Centric Role: Coordinate and organize administrative tasks to ensure smooth delivery of gene therapy services
Oncology
Director of Oncology Marketing — Natera
Strategic Impact: This is a hands-on leadership role where you drive go-to-market for flagship genomic products—directly shaping physicians' and payers' perceptions and supporting the launch of next-generation technologies
Cross-Functional Collaboration: You'll work with medical, commercial, product, and data science teams—a rare chance to inform nearly every aspect of the business and influence how complex science is marketed to multiple stakeholders
Innovation Focus: Leading marketing efforts for comprehensive genomic profiling and MRD testing platforms
Area Business Director, Northeast — Revolution Medicines
Growth Company: Prominent leadership at a company with first-in-class oncology focus targeting RAS-addicted cancers
Leadership: High influence in territory go-to-market strategy and team mentoring across 8 Sales Representatives
Geographic Coverage: Illinois, Iowa, Minnesota, South Dakota, North Dakota, Montana, Nebraska, Wyoming, Idaho, Utah, and partial coverage of Washington, Missouri, Indiana, Kansas
Uro Oncology Business Manager, Pittsburgh — ImmunityBio
Commercial Launch: Drive clinical conviction of Anktiva for early-stage bladder cancer patients
Strategic Territory: Pittsburgh territory management with focus on LUGPA clinics, Academic institutions, and IDN Hospitals
Breakthrough Innovation: Working with next-generation treatments for cancer and infectious diseases
Your Competitive Edge, Delivered Weekly
This round-up extends our newsletter's proven approach: quality over quantity, insight over information. While job aggregators throw hundreds of listings at you, we deliver the 10-15 opportunities each week that actually matter for your career trajectory.
Because in biotech, it's not about finding a job – it's about finding the right opportunity at the right time with the right company that positions you for the next decade of your career.
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The YGC Team