Welcome to The YGC's Hiring Brief – Your Gateway to Biotech's Newest Opportunities | August 29, 2025
This isn’t scraped content. Every role here is vetted through YGC’s insider network — these are the opportunities that actually move careers forward.
The job market moves fast. Your career should move faster.
Each week, we curate the hottest roles in rare disease, gene therapy, oncology, and specialty biopharma — not scraped lists, but insider intel vetted through our network. These are the opportunities that matter: high-impact roles at lean, growing companies where disruption creates opportunity.
While others are slowing down, the real moves are happening now — here are the roles worth your attention.
This Week’s Featured Roles
High-Impact Commercial Roles Hiring Right Now in Rare Disease, Gene Therapy, Oncology & Specialty Biopharma
All jobs are active listings at powerful mission-driven teams. Check them out!
Rare Disease
Pharmaceutical Sales Rep, Endocrinology (Rare Disease) - Milwaukee — Xeris
Company Trajectory:
49% YoY Revenue Growth to $71.5M in Q2 2025, with 82.2% gross margins
Recorlev® Success: 136% YoY growth treating Cushing's syndrome with 7-year orphan drug exclusivity
Billion-Dollar Pipeline: XP-8121 targeting $10B hypothyroidism market, Phase 3-ready with $1-3B peak revenue potential
Financial Stability: Positive adjusted EBITDA and disciplined capital allocation
Senior Director, US HCP Marketing Indication Lead — argenx
Why This Role Is Exceptional:
Company Momentum: argenx is riding the wave of VYVGART's commercial success, with the first-in-class neonatal Fc receptor blocker approved for generalized myasthenia gravis (gMG) and chronic inflammatory demyelinating polyneuropathy (CIDP)
Market Opportunity: Targeting dozens of severe autoimmune diseases with a revolutionary mechanism of action
Celebrity Partnership: Tennis legend Monica Seles became their public advocate, massively amplifying brand awareness
Career Growth: Leading HCP strategy for a transformative rare disease therapy in a rapidly expanding company
Head of Market Access & Patient Services — Dyne Therapeutics
Company Intelligence:
$3.5B Market Cap with groundbreaking FORCE™ platform technology
FDA Breakthrough Therapy Designation for DYNE-251 in Duchenne muscular dystrophy
Pipeline Catalyst: DYNE-251 showing unprecedented dystrophin expression levels, targeting BLA submission in early 2026
Strategic Timing: Market access leadership during commercial transition phase offers exceptional career leverage
Director, Field Reimbursement Lead, South — Alnylam
Market Position:
RNAi Leader: Established platform with multiple approved therapies for rare diseases
Reimbursement Expertise: Critical role managing complex payer relationships for high-cost rare disease therapies
Geographic Advantage: Southern territory coverage offers broad market exposure
Rare Disease Account Manager, Birmingham — Calliditas
Niche Positioning:
Specialized Focus: Dedicated rare disease commercial strategy
Regional Leadership: Alabama territory management for emerging rare disease therapies
Growth Market: Expanding rare disease treatment landscape
Care Coordinator, Patient Care Navigation — Krystal
Mission-Driven: Direct patient impact for ultra-rare, previously untreatable conditions.
Biotech Growth: Become part of a company pioneering redosable gene therapy.
Gene Therapy
SVP Commercial — UniQure
Gene Therapy Leadership: This is a chance to launch an industry-defining product in a white space market, shaping a new standard for ultra-rare CNS diseases.
Build From Scratch: The SVP will recruit talent, foster culture, and design organizational strategy from launch onward—a rare opportunity to own blueprint-level work.
Pivotal Impact: You’ll collaborate frequently with C-suite and board, impacting UniQure’s organizational trajectory at a transformative time.
Compensation and Growth: SVP roles in gene therapy offer competitive packages, equity, and direct visibility to future CEO paths.
Vice President, US Regional Account Management — UniQure
Why It’s Attractive:
Frontline Leadership: Direct access to regional teams at launch, bridging strategy and real-world execution.
Rare Disease Commercialization: Uniquely focused on selling specialty therapies to treatment centers—high visibility and impact.
Talent Builder: Influence the next generation of sales/account leadership, fostering a culture of excellence and collaboration.
Director, New Product Planning — uniQure
Cross-Functional Opportunity:
Portfolio Shaper: Directly influences which gene therapy assets move forward, impacting future company growth.
Strategic Exposure: Collaborates deeply with R&D, clinical, regulatory, commercial, and BD—all the decision-makers in biotech product development.
Innovation Environment: Ideal for commercial leaders who thrive in high-growth, science-driven settings where new launches are routine.
Oncology
Director of Oncology Marketing — Natera
Strategic Impact: This is a hands-on leadership role where you drive go-to-market for a flagship genomic product—directly shaping physicians’ and payers’ perceptions and supporting the launch of next-generation technologies.
Cross-Functional Collaboration: You’ll work with medical, commercial, product, and data science teams—a rare chance to inform nearly every aspect of the business and influence how complex science is marketed to multiple stakeholders.
Area Business Director, Prairie — Revolution Medicines
Growth Company: Prominent leadership at a company with a first-in-class oncology focus.
Leadership: High influence in territory go-to-market strategy and team mentoring.
Medical Science Liaison, Breast Oncology — Natera
Scientific Excellence:
Precision Medicine: Leading liquid biopsy and genetic testing technologies
Clinical Impact: Direct physician education on breakthrough diagnostic technologies
Oncology Focus: High-growth therapeutic area with significant unmet needs
🧠 Heads-up: Most of these teams have multiple roles open. Click through their sites for full listings.
Your Competitive Edge, Delivered Weekly
This round-up extends our newsletter's proven approach: quality over quantity, insight over information. While job aggregators throw hundreds of listings at you, we deliver the 10-15 opportunities each week that actually matter for your career trajectory.
Because in biotech, it's not about finding a job – it's about finding the right opportunity at the right time with the right company that positions you for the next decade of your career.
Ready to get ahead while others are standing still?
Don't miss a single opportunity. Subscribe to our newsletter delivered directly to your inbox every Friday, now improved with this special list of handpicked roles you don’t want to miss.
Stay Visible,
The YGC Team